Jerzy Twarowski
Welcome
Welcome to my website. I am a PhD candidate at The University of Iowa with a focus on mutagenesis during meiotic DNA repair and recombination. My current research investigates mechanisms creating hypermutable single-stranded DNA in meiosis of yeast Saccharomyces cerevisiae, with the goal of advancing our understanding of genomic stability, disease and evolution. My broader work includes developing algorithms and pipelines for genomic analysis, studying DNA double strand break (DSB) repair and mutagenesis in both yeast and cancer. Please feel free to explore my research and publications.
My Resume
If you would like to learn more about my qualifications and experience, I invite you to take a look at my resume, which is attached on this website. It provides an overview of my education, work experience, publications, presentations, and skills. It also includes my contact information, should you wish to reach out to me for any further information or potential collaborations/job opportunities. I am eager to connect with potential collaborators and employers, and I am happy to share more about my work and experience.
JT Resume Fall 2024.pdfPublications
v Twarowski, J.M., Kramara, J., Seuferer, G., Jiman, J., Malkova, A. Break-induced replication forms long hypermutable single-strand (ss) DNA during meiosis. Nature Communications (in review)
v Liu, L., Lee, R.S., Twarowski, J.M., Wells, J., Jiman, J., Stefen, J., Lobachev, K., Malkova, A. New Genes Discovered to Regulate Break-induced Replication Through Yeast Whole Genome Screen. Nature Communications (in review)
v Lee, R.S., Twarowski, J.M., Malkova, A. (2024) Stressed? Break-Induced Replication comes to the rescue! DNA Repair 10.1016/j.dnarep.2024.103759 article link
v Lee, R.S., Geronimo, C., Twarowski, J.M., Malkova, A., Zakian, V., (2023). Identification of the nuclear localization signal in the Saccharomyces cerevisiae Pif1 DNA helicase. PloS Genetics 10.1371/journal.pgen.1010853 article link
v Deshpande M, Paniza T, Jalloul N, Nanjangud G, Twarowski J, Koren A, Zaninovic N, Zhan Q, Chadalavada K, Malkova A, Khiabanian H, Madireddy A, Rosenwaks Z, Gerhardt J. (2022). Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells. Molecular Cell 10.1016/j.molcel.2022.08.017 article link
v Osia*, B., Twarowski*, J., Jackson, T., Lobachev, K., Liu, L., Malkova, A. (2022). Migrating bubble synthesis promotes mutagenesis through lesions in its template. Nucleic Acid Research 50-12, 6870–6889. (*First Co-Authors) article link
v Liu, L., Yan, Z., Osia, B., Twarowski, J., Sun, L., Kramara, J., Lee, R., Kumar, S., Elango, R., Li, H., Dang, W., Ira, G., Malkova, A. (2021). Tracking break-induced replication shows that it stalls at roadblocks. Nature 590, 655–659 article link