Jerzy Twarowski

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Welcome

Thank you for visiting my website! My name is Jerzy M. Twarowski and I am a Ph.D. candidate in the Department of Biology at The University of Iowa. My research focuses on understanding DNA break repair through a combination of molecular biology and bioinformatic approaches. Specifically, I am currently investigating Break Induced Replication (BIR) in Saccharomyces cerevisiae, using innovative methods to collect and analyze data, identify new BIR players and mechanisms, and establish various bioinformatic pipelines for genetic variant discovery, annotation, and analysis. Furthermore, I am also investigating Microhomology-mediated break-induced replication (MMBIR) signatures in Next Generation Sequencing (NGS) databases of human cancers. I hope this website provides you with a better understanding of my research and qualifications, and I am happy to connect with potential collaborators or employers.

My Resume

If you would like to learn more about my qualifications and experience, I invite you to take a look at my CV, which is attached on this website. My CV provides a comprehensive overview of my education, work experience, publications, presentations, and skills. It also includes my contact information, should you wish to reach out to me for any further information or potential collaborations/job opportunities. I am eager to connect with potential collaborators and employers, and I am happy to share more about my work and experience.

Thank you for your time and consideration.

resume Fall 2022.pdf

Publications

  • Liu, L., Yan, Z., Osia, B., Twarowski, J., Sun, L., Kramara, J., Lee, R., Kumar, S., Elango, R., Li, H., Dang, W., Ira, G., Malkova, A. (2021). Tracking break-induced replication shows that it stalls at roadblocks. Nature 590, 655–659. Direct Link

  • Osia*, B., Twarowski*, J., Jackson, T., Lobachev, K., Liu, L., Malkova, A. (2022). Migrating bubble synthesis promotes mutagenesis through lesions in its template. Nucleic Acid Research 50-12, 6870–6889. (*First Co-Authors). Direct Link

  • Deshpande, M., Paniza, T., Jalloul, N., Nanjangud, G., Twarowski, J., Koren, A., Zaninovic, N., Zhan, Q., Chadalavada, K., Malkova, A., Khiabanian, H., Madireddy, A., Rosenwaks, Z., Gerhardt, J. (2022). Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells. Molecular Cell 10.1016/j.molcel.2022.08.017 Direct Link

  • Lee, R.S., Geronimo, C., Twarowski, J.M., Malkova, A., Zakian, V., (2022). Identification of the nuclear localization signal in the Saccharomyces cerevisiae Pif1 DNA helicase. PloS Genetics (under revision)